The chemistry laboratories are located at Hyderabad and at six regional centers at New Delhi, Bangalore, Shillong, Nagpur, Jaipur and Jamshedpur.

The laboratory at Hyderabad is equipped with instruments like Fluorometer (optical and laser), Atomic Absorption Spectrophotometer (AAS), Inductively Coupled Plasma Emission Spectrometer (ICPAES), Molecular Absorption Spectrophotometer, Flame photometer, Mercury analyser etc. The instrument ICP–AES is also available at Bangalore, Nagpur, New Delhi and Shillong. The other instruments e.g. Fluorometer, AAS, Molecular Absorption Spectrophotometer and flame photometer are available in all the regional centers.

Over the years, an excellent interface of man and machine has resulted in generating a fair level of expertise in the determination of elements like U, Th, Be, Nb, Ta, W, Mo, Zr, alkali metals, alkaline earths, 1^st series transition elements (Sc-Zn), rare earth elements (including Y), As, Se, B, Ga, Ge, Sn , Pb, Bi etc., in the range from parts per billion for some to percentage level for others.

The research works  from the laboratory have resulted in developing new procedure as well as in improving the existing methods of analysis. About sixty elements of the periodic table are within the routine reach of this laboratory and the dependability of data is as good as anywhere else. Currently, the laboratory at Hyderabad is engaged to standardise suitable procedures for estimation of platinum group elements by Fire Assay technique and also to procure ICPMS to augment the analytical output.